The Chemistry functions at Icagen have two main objectives: The primary goal is to support exploration and optimization of chemical entities to ensure their fast progression to the next pipeline milestone, typically to Lead or Pre-Candidate status. Such support involves a broad expertise in Medicinal Chemistry and multi-parametric optimization of compound properties.
The second objective entails the expansion and enrichment of the Icagen chemical estate of small molecules. Our repository of commercial and proprietary chemical modalities is the fuel that powers our drug discovery campaigns via high- and ultra-high-throughput screening. Concepts for new chemical entities are derived from peer reviewed and patent publications, internal medicinal chemistry optimization campaigns, and by engineering privileged chemical scaffolds to create proprietary positions.