PUBLICATIONS

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Grant A. McNaughton-Smith, J. Ford Burns, Jonathan W. Stocker, Gregory C. Rigdon, Christopher Creech, Susan Arrington, Tara Shelton, Lucia de Franceschi

Novel Inhibitors of the Gardos Channel for the Treatment of Sickle Cell Disease

 J. Med.Chem. 2008, 51, 976–982

Wickenden AD., Krajewski J., London B., Wagoner P.K., Wilson W.A., Clark S., Roeloffs R., McNaugton-Smith G., Rigdon G.C.
N-(6-Chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): A Novel, Selective KCNQ2/Q3 Potassium Channel Activator
Mol Pharmacol.2008; 73: 977-986

Krafte DS, Bannon AW.
Sodium channels and nociception; recent concepts and therapeutic opportunitites.
Current Opinion in Pharmcology, 2008, 8:50-56

Kenneth I Ataga, Wally R. Smith, Laura M De Castro, Paul Swerdlow, Yogen Saunthararajah, Oswaldo Castro, Elliot Vichinsky, Abdullah Kutlar, Eugene P. Orringer, Greg C Rigdon and Jonathan W. Stocker

Efficacy and safety of the Gardos channel blocker, Senicapoc (ICA-17043), in patients with sickle cell anemia

Blood doi;10.1182/blood-2007-08-110098

Jarvis M, Honore P, Shieh C, Chapman M,Joshi S, Zhang X, Kort M, Carroll W,

Marron B, Atkinson A, Thomas J, Liu D, Krambis M, Liu Y, McGaraughty S, Chu K, Roeloffs R, Zhong C, Mikusa J, Hernandez G, Gauvin D, Wade C, Zhu C, Pai M, Scanio M, Shi L, Drizin I, Gregg R, Matulenko M, Hakeem A, Gross M, Johnson M, Marsh K, Wagoner K, Sullivan J, Falynek C, Krafte D.

A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat.

PNAS published online, 2007

Gross M, Beaudoin S, McNaughton-Smith G, Amato G, Castle N, Huang C, Zou A,

Yu W.
Aryl Sulfonamido Indane Inhibitors of the Kv1.5 Ion Channel.
Bioorganic & medicinal chemistry letters, 17, 2849, 2007

Castle N.
Aquaporins as targets for drug discovery.
Drug Discovery Today 10: 485-493, 2005.

Wickenden AD, Roeloffs R, McNaughton-Smith G, Rigdon GC.
KCNQ potassium channels: drug targets for the treatment of epilepsy and pain.
Expert Opin. Ther. Patents. 14: 457-469, 2004.

Gopalakrishnan M, Buckner SA, Shieh CC, Fey T, Fabiyi A, Whiteaker KL, Davis-Taber R, Milicic I, Daza AV, Scott VE, Castle NA, Printzenhoff D, London B, Turner SC, Carroll WA, Sullivan JP, Coghlan MJ, Brune ME.
In vitro and in vivo characterization of a novel naphthylamide ATP-sensitive K+ channel opener, A-151892.
Br J Pharmacol. 143:81-90 2004.

Stocker JW, De Franceschi L, McNaughton-Smith G, Corrocher R, Beauzard Y, Brugnara C.
ICA-17043, a novel Gardos channel blocker, prevents sickled red blood cells dehydration in vitro and in vivo in SAD mice.
Blood 101(6):2412-2418, 2003

Beaudoin S, Kinsey KE, Burns JF.
Preparation of unsymmetrical sulfonylureas from N, N'-Sulfuryldiimidazoles
Journal of Organic Chemistry. 68(1):115-119, 2003

Castle NA, London DO, Creech C, Fajloun Z, Stocker JW, Sabatier JM.
Maurotoxin: a potent inhibitor of intermediate conductance Ca2+ -activated potassium channels
Molecular Pharmacology. 63:409-18, 2003

Hadley JK, Passmore GM, Tatulian L, Al-Qatari M, Ye F, Wickenden AD, Brown DA.
Stoichiometry of expressed KCNQ2/KCNQ3 potassium channels and subunit composition of native ganglionic M channels deduced from block by tetraethylammonium
Journal of Neuroscience. 23(12):5012-9, 2003

Turner SC, Carroll WA, White TK, Brune ME, Buckner SA, Gopalakrishnan M, Fabiyi A, Coghlan MJ, Scott VE, Castle NA, Daza AV, Milicic I, Sullivan JP.
Structure-activity relationship of a novel class of naphthyl amide K(ATP) channel openers
Bioorganic Medicinal Chemistry Letters. 13:1741-4, 2003

van Rhee AM.
Use of recursion forests in the sequential screening process: consensus selection by multiple recursion trees
Journal of Chemical Information and Computer Sciences. 43:941-948, 2003

Zou A, Lin Z, Humble M, Creech C, Wagoner PK, Krafte D, Jegla T, Wickenden A.
Distribution and functional properties of human KCNH8 (Elk1) potassium channels
American Journal of Physiology (Cell Physiology). 285:C1356-C1366, 2003

Wickenden AD.
Potassium channels as anti-epileptic drug targets (Invited Review)
Neuropharmacology. 43(7):1055-60, 2003

Liu Y, Liu D, Krafte DS.
Decrease of inward rectification as a mechanism for arachidonic acid-induced potentiation of hKir2.3
European Biophysics Journal. 31(7):497-503, 2003

Gopalakrishnan M, Buckner SA, Whiteaker KL, Shieh CC, Molinari EJ, Milicic I, Daza AV, Davis-Taber R, Scott VE, Sellers D, Chess-Williams R, Chapple CR, Liu Y, Liu D, Brioni JD, Sullivan JP, Williams M, Carroll WA, Coghlan MJ.
(-)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7, 9-hexahydrothieno[3,2-b]quinolin-8(4H) -one 1,1-dioxide (A-278637): a novel ATP-sensitive potassium channel opener efficacious in suppressing urinary bladder contractions. I. In vitro characterization
Journal of Pharmacology and Experimental Therapeutics. 303:379-386, 2003

Wickenden AD.
Potassium channels as therapeutic drug targets. (Invited review)
Pharmacology & Therapeutics.94 :157-182, 2002

Liu Y, Liu D, Heath L, Meyers DM, Krafte DS, Wagoner PK, Silvia CP, Yu W, Curran ME.
Direct activation of an inwardly rectifying potassium channel by arachidonic acid
Molecular Pharmacology. 59(5):1061-1068, 2001

Liu Y, Liu D, Printzenhoff D, Coghlan MJ, Harris R, Krafte DS.
Tenidap, a novel anti-inflammatory agent, is an opener of the inwardly rectifying K+ channel hKir2.3
European Journal of Pharmacology. 435:153-160, 2002

Wickenden A, Zou A, Wagoner PK, Jegla T.
Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells
British Journal of Pharmacology. 132: 381-384, 2001

van Rhee MA, Stocker J, Printzenhoff D, Creech C, Wagoner PK, Spear KL.
Retrospective analysis of an experimental high-throughput screening data set by recursive partitioning
Journal of Combinatorial Chemistry. 3(3):267-277, 2001

Brenner R, Jegla TJ, Wickenden A, Liu Y, Aldrich RW.
Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4
Journal of Biological Chemistry. 275(9):6453-61, 2000

Packer J, Conley E, Castle N, Wray D, January C, Patmore, L.
Internet resources for exploring gene family diversity
Trends in Pharmacological Sciences. 21: 327-329, 2000

Wickenden AD, Yu W, Zou A, Jegla T, Wagoner PK.
Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels
Molecular Pharmacology. 58(3): 591-600, 2000

Castle NA.
Recent advances in the biology of small conductance calcium-activated potassium channels. (Invited Review)
Perspectives in Drug Discovery and Design. 15/16:131-154, 1999

Wickenden AD, Jegla TJ, Kaprielian R, Backx PH.
Regional contributions of Kv1.4, Kv4.2, and Kv4.3 to transient outward K+ current in rat ventricle
American Journal Physiology. 276(5-2): H1599-1607,1999