Tools & Technologies
Comprehensive platform of assay technologies, tools and reagents
Icagen has a large platform of drug discovery tools and technologies covering chemistry, biology, in silico drug discovery, compound logistics, analytics, and assays for interrogation of ion channel and transporter function and pharmacological modulation. THis includes high-performance computational suites, ultra high throughput screening (uHTS), and our proprietary XRpro® label-free X-ray technology.
Icagen has built an extensive portfolio of over 1000 cell lines. It includes cell lines stably expressing recombinant human ion channels and transporters, species orthologs and distinct disease-related or drug binding site mutants. These tools form the basis for compound screening, selectivity assays, detailed assessment of activity, and mechanism of action studies.
Our proprietary XRpro® is a label-free technology that leverages the unique capabilities of X-ray fluorescence for high-throughput ion flux assays. XRpro technology directly measures elements across the periodic table, from monovalent and divalent ions including potassium and calcium to halogens and transition metals including zinc. Combined with the penetrating ability of X-rays to deal with complex solutions including 100% serum, the system enables analysis of electrogenic and nonelectrogenic systems that challenge other technologies.Learn More
Icagen offers a full complement of assay technologies including high throughput fluorescence, manual and automated electrophysiology, and radiotracer flux assays. Combined with our cell line and assay development expertise, these technologies enable Icagen to rapidly provide quality screening for a broad set of ion channels and transporters.