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Ion-pulling simulations provide insights into the mechanisms of channel opening of the skeletal muscle ryanodine receptor

David D. Mowrey, Le Xu, Yingwu Mei, Daniel A. Pasek, Gerhard Meissner, and Nikolay V. Dokholyan

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The discovery of a potent Nav1.3 inhibitor with good oral pharmacokinetics

D. C. Pryde, N. A. Swain, P. A. Stupple, C. W. West, B. Marron, C. J. Markworth, D. Printzenhoff, Z. Lin, P. J. Cox, R. Suzuki, S. McMurray, G. J. Waldron, C. E. Payne, J. S. Warmus and M. L. Chapman

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The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels

Jonathan W. Theile, Matthew D. Fuller, and Mark L. Chapman

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Biophysical and Pharmacological Characterization of Nav1.9 Voltage Dependent Sodium Channels Stably Expressed in HEK-293 Cells

Zhixin Lin, Sonia Santos, Karen Padilla, David Printzenhoff, Neil A. Castle

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Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release

Aristos J. Alexandrou, Adam R. Brown, Mark L. Chapman, Mark Estacion, Jamie Turner, Malgorzata A. Mis, Anna Wilbrey, Elizabeth C. Payne, Alex Gutteridge, Peter J. Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E. Marron, Christopher West, Nigel A. Swain, R. Ian Storer, Paul Stupple, Neil A. Castle, James A. Hounshell, Mirko Rivara, Andrew Randall, Sulayman D. Dib-Hajj, Douglas Krafte, Stephen G. Waxman, Manoj K. Patel, Richard P. Butt, Edward B. Stevens

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APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases

Opeyemi A. Olabisi, Jia-Yue Zhang, Lynn VerPlank, Nathan Zahler, Salvatore DiBartolo III, John F. Heneghan, Johannes S. Schlöndorff, Jung Hee Suh, Paul Yan, Seth L. Alper, David J. Friedman, and Martin R. Pollak

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Validation of ion channel targets

Aaron C Gerlach and Brett M Antonio

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A novel selective and orally bioavailable Nav1.8 channel blocker, PF-01247324, attenuates nociception and sensory neuron excitability

Claire Elizabeth Payne, Adam R Brown, Jonathon W Theile, Alexandre J C Loucif, Aristos J Alexandrou, Mathew D Fuller, John H Mahoney, Brett M Antonio, Aaron C Gerlach, David M Printzenhoff, Rebecca L Prime, Gillian Stockbridge, Anthony J Kirkup, Anthony W Bannon, Steve England, Mark L Chapman, Sharan Bagal, Rosemarie Roeloffs, Uma Anand, Praveen Anand, Peter J Bungay, Mark Kemp, Richard P Butt and Edward B Stevens

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SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases

Jean-Christophe Carry, Franco̧is Clerc, Hervé Minoux, Laurent Schio, Jacques Mauger, Anil Nair, Eric Parmantier, Ronan LeMoigne, Cécile Delorme, Jean-Paul Nicolas, Alain Krick, Pierre-Yves Abećassis, Véronique Crocq-Stuerga, Stéphanie Pouzieux, Laure Delarbre, Sébastien Maignan, Thomas Bertrand, Kirsten Bjergarde, Nina Ma,Sylvette Lachaud, Houlfa Guizani, Reḿi Lebel, Gilles Doerflinger, Sylvie Monget, Sebastien Perron, Francis Gasse, Odile Angouillant-Boniface, Bruno Filoche-Romme,́ Michel Murer, Sylvie Gontier, CeĺinePrev́ost, Marie-Line Monteiro, Cećile Combeau

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Rapid Identification of Metal-Binding Peptoid Oligomers by On-Resin X-Ray Fluorescence Screening

Danielle M. Nalband, Benjamin P. Warner, Nathan H. Zahler, Kent Kirshenbaum

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