Publications

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    β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

    Jul 19, 2019

    Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan

    Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

    Dec 19, 2018

    Aditya J. Desai, Ingrid Mechin, Karthigeyan Nagarajan, Celine Valant, Denise Wootten, Polo C. H. Lam, Andrew Orry, Ruben Abagyan, Anil Nair, Patrick M. Sexton, Arthur Christopoulos, and Laurence J. Miller

    High Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance

    Nov 01, 2018

    Carlos G. Vanoye, PhD, Reshma R. Desai, MS, Katarina L. Fabre, MS, Shannon L. Gallagher, MS, Franck Potet, PhD, Jean-Marc DeKeyser, MS, Daniela Macaya, PhD, Jens Meiler, PhD, Charles R. Sanders, PhD, and Alfred L. George Jr., MD

    TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype

    Oct 19, 2018

    Wei Chou Tseng, David C. Pryde, Katrina E. Yoger, Karen M. Padilla, Brett M. Antonio, Seungil Han, Veerabahu Shanmugasundaram, and Aaron C. Gerlach

    p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2

    Aug 20, 2018

    E. W. Cloer, P. F. Siesser, E. M. Cousins, D. Goldfarb, D. D. Mowrey, J. S. Harrison, S. J. Weir, N. V. Dokholyan, M. B. Majora

    PF-06526290 can both enhance and inhibit conduction through voltage-gated sodium channels

    Mar 17, 2018

    Lingxin Wang, Shannon G Zellmer, David M Printzenhoff and Neil A Castle

    A comprehensive Approach to Identifying Repurposed Drugs to Treat SCN8A Epilepsy

    Feb 05, 2018

    Talia A. Atkin, Chani M. Maher, Aaron C. Gerlach, Bryant C. Gay, Brett M. Antonio, Sonia C. Santos, Karen M. Padilla, JulieAnn Rader, Douglas S. Krafte, Matthew A. Fox, Gregory R. Stewart, Slavé Petrovski, Orrin Devinsky, Matthew Might, Steven Petrou, David B. Goldstein

    Discovery and in Vitro Optimization of 3‐Sulfamoylbenzamides as ROMK Inhibitors

    Jan 19, 2018

    Matthew F. Sammons, Sujay V. Kharade, Kevin J. Filipski, Markus Boehm, Aaron C. Smith, Andre Shavnya, Dilinie P. Fernando, Matthew S. Dowling, Philip A. Carpino, Neil A. Castle, Shannon G. Zellmer, Brett M. Antonio, James R. Gosset, Anthony Carlo, and Jerod S. Denton

    G4941K substitution in the pore-lining S6 helix of the skeletal muscle ryanodine receptor increases RyR1 sensitivity to cytosolic and luminal Ca2+

    Dec 18, 2017

    Le Xu, David D. Mowrey, Venkat R. Chirasani, Ying Wang, Daniel A. Pasek, Nikolay V. Dokholyan, and Gerhard Meissner

    GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability

    Nov 19, 2017

    Alexandre J C Loucif, Pierre-Philippe Saintot, Jia Liu, Brett M Antonio, Shannon G Zellmer, Katrina Yoger, Emma L Veale, Anna Wilbrey, Kiyoyuki Omoto, Lishuang Cao, Alex Gutteridge, Neil A Castle, Edward B Stevens, Alistair Matie