Publications

Filter By:

Search:

Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series

Andrew M. Griffin, Kristopher M. Kahlig, Robert John Hatch, Zoë A. Hughes, Mark L. Chapman, Brett Antonio, Brian E. Marron, Marion Wittmann, and Gabriel Martinez-Botella

View Article

The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease

Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser

View Article

Repurposing Approved Drugs as Inhibitors of Kv7.1 and Nav1.8 To Treat Pitt Hopkins Syndrome

Sean Ekins, Jacob Gerlach, Kimberley M. Zorn, Brett M. Antonio, Zhixin Lin, Aaron Gerlach

View Article

Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function

Somenath Datta, Rama Kataria, Jia-Yue Zhang, Savannah Moore, Kaitlyn Petitpas, Adam Mohamed, Nathan Zahler, Martin R. Pollak, Opeyemi A. Olabisi

View Article

Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation

Santoshi Billakota, J. Michael Andresen, Bryant C. Gay, Gregory R. Stewart, Nikolai B. Fedorov, Aaron C. Gerlach, Orrin Devinsky

View Article

Inter-Active Site Communication Mediated by the Dimer Interface Beta-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase.

Paul J. Sapienza, Konstantin I. Popov, David D. Mowrey, Bradley T. Falk, Nikolay V. Dokholyan, Andrew L. Lee

View Article

Modification of messenger RNA by 2′-O- methylation regulates gene expression in vivo

Brittany A. Elliott, Hsiang-Ting Ho, Srivathsan V. Ranganathan, Sweta Vangaveti, Olga Ilkayeva, Hala Abou Assi, Alex K. Choi, Paul F. Agris & Christopher L. Holley

View Article

β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology

Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan

View Article

Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor

Aditya J. Desai, Ingrid Mechin, Karthigeyan Nagarajan, Celine Valant, Denise Wootten, Polo C. H. Lam, Andrew Orry, Ruben Abagyan, Anil Nair, Patrick M. Sexton, Arthur Christopoulos, and Laurence J. Miller

View Article

High Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance

Carlos G. Vanoye, PhD, Reshma R. Desai, MS, Katarina L. Fabre, MS, Shannon L. Gallagher, MS, Franck Potet, PhD, Jean-Marc DeKeyser, MS, Daniela Macaya, PhD, Jens Meiler, PhD, Charles R. Sanders, PhD, and Alfred L. George Jr., MD

View Article