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Small-molecule eRF3a degraders rescue CFTR nonsense mutations by promoting premature termination codon readthrough
Rhianna E Lee, Catherine A Lewis, Lihua He, Emily C Bulik-Sullivan, Samuel C Gallant, Teresa M Mascenik, Hong Dang, Deborah M Cholon, Martina Gentzsch, Lisa C Morton, John T Minges, Jonathan W Theile, Neil A Castle, Michael R Knowles, Adam J Kimple, Scott H Randell
09.15.2022
A-type FHFs mediate resurgent currents through TTX-resistant voltage-gated sodium channels
Yucheng Xiao, Jonathan W Theile, Agnes Zybura, Yanling Pan, Zhixin Lin, Theodore R Cummins
04.20.2022
LIGAND AND GSK EXPAND GLOBAL COLLABORATION AND LICENSE AGREEMENT
Ligand to receive an upfront payment of $10 million Further leverages the Icagen ion-channel discovery technology to target neurological diseases EMERYVILLE, Calif.–(BUSINESS WIRE)– Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announced today the expansion of an existing collaboration and license agreement between its subsidiary, Icagen, and GlaxoSmithKline (GSK). The expansion will leverage Icagen’s ion-channel-based discovery technology and unique expertise …
12.21.2021
Discovery of the First Orally Available, Selective KNa1.1 Inhibitor: In Vitro and In Vivo Activity of an Oxadiazole Series
Andrew M. Griffin, Kristopher M. Kahlig, Robert John Hatch, Zoë A. Hughes, Mark L. Chapman, Brett Antonio, Brian E. Marron, Marion Wittmann, and Gabriel Martinez-Botella
03.01.2021
LIGAND AND GSK ENTER GLOBAL COLLABORATION AND LICENSE AGREEMENT LEVERAGING ICAGEN’S DISCOVERY TECHNOLOGY TO TARGET NEUROLOGICAL DISORDERS
Ligand Group is eligible to receive an upfront payment of $7 million and potential milestone payments and fees of up to $154.5 million and tiered royalties SAN DIEGO–(BUSINESS WIRE)– Ligand Pharmaceuticals Incorporated (NASDAQ: LGND) announced today a collaboration and license agreement between its subsidiary, Icagen, and GlaxoSmithKline (GSK) to leverage Icagen’s unique expertise in small molecule therapeutics …
12.21.2020
The M1311V variant of ATP7A is associated with impaired trafficking and copper homeostasis in models of motor neuron disease
Nadine Bakkar, Alexander Starr, Benjamin E. Rabichow, Ileana Lorenzini, Zachary T. McEachin, Robert Kraft, Matthew Chaung, Sam Macklin-Isquierdo, Taylor Wingfield, Briggs Carhart, Nathan Zahler, Wen-Hsuan Chang, Gary J. Bassell, Alexandre Betourne, Nicholas Boulis, Samuel V. Alworth, Justin K. Ichida, Paul R. August, Daniela C. Zarnescu, Rita Sattler, Robert Bowser
12.17.2020
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