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Repurposing Approved Drugs as Inhibitors of Kv7.1 and Nav1.8 To Treat Pitt Hopkins Syndrome
Sean Ekins, Jacob Gerlach, Kimberley M. Zorn, Brett M. Antonio, Zhixin Lin, Aaron Gerlach
07.22.2020
Kidney Disease-Associated APOL1 Variants Have Dose-Dependent, Dominant Toxic Gain-of-Function
Somenath Datta, Rama Kataria, Jia-Yue Zhang, Savannah Moore, Kaitlyn Petitpas, Adam Mohamed, Nathan Zahler, Martin R. Pollak, Opeyemi A. Olabisi
05.12.2020
Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation
Santoshi Billakota, J. Michael Andresen, Bryant C. Gay, Gregory R. Stewart, Nikolai B. Fedorov, Aaron C. Gerlach, Orrin Devinsky
10.28.2019
Modification of messenger RNA by 2′-O- methylation regulates gene expression in vivo
Brittany A. Elliott, Hsiang-Ting Ho, Srivathsan V. Ranganathan, Sweta Vangaveti, Olga Ilkayeva, Hala Abou Assi, Alex K. Choi, Paul F. Agris & Christopher L. Holley
07.30.2019
Inter-Active Site Communication Mediated by the Dimer Interface Beta-Sheet in the Half-the-Sites Enzyme, Thymidylate Synthase.
Paul J. Sapienza, Konstantin I. Popov, David D. Mowrey, Bradley T. Falk, Nikolay V. Dokholyan, Andrew L. Lee
β-Methylamino-L-alanine substitution of serine in SOD1 suggests a direct role in ALS etiology
Elizabeth A. Proctor, David D. Mowrey, Nikolay V. Dokholyan
07.19.2019
Molecular Basis of Action of a Small-Molecule Positive Allosteric Modulator Agonist at the Type 1 Cholecystokinin Holoreceptor
Aditya J. Desai, Ingrid Mechin, Karthigeyan Nagarajan, Celine Valant, Denise Wootten, Polo C. H. Lam, Andrew Orry, Ruben Abagyan, Anil Nair, Patrick M. Sexton, Arthur Christopoulos, and Laurence J. Miller
12.19.2018
High Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance
Carlos G. Vanoye, PhD, Reshma R. Desai, MS, Katarina L. Fabre, MS, Shannon L. Gallagher, MS, Franck Potet, PhD, Jean-Marc DeKeyser, MS, Daniela Macaya, PhD, Jens Meiler, PhD, Charles R. Sanders, PhD, and Alfred L. George Jr., MD
11.01.2018
TRPA1 ankyrin repeat six interacts with a small molecule inhibitor chemotype
Wei Chou Tseng, David C. Pryde, Katrina E. Yoger, Karen M. Padilla, Brett M. Antonio, Seungil Han, Veerabahu Shanmugasundaram, and Aaron C. Gerlach
10.19.2018
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